Age-related degradation of skeletal muscles known as sarcopenia is more common after 50. Muscle atrophy is one aspect of sarcopenia as individual’s muscle mass can reduce by 1% each year. Quality of muscle tissue is the other aspect as fat and fibrosis replace the muscle fibers. Finally muscle function can degrade as another aspect of sarcopenia due to changes in muscle metabolism, degeneration of neuromuscular junction and oxidative stress. Leg muscles such as quadriceps are more affected by age than arm and upper body. Exercise and appropriate nutrition with protein are helpful in preserving muscles and may improve muscle function and patient mobility and quality of life.